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Urgent Need for Newborn Antibiotics: Insights from Global Health Experts

  • May 3, 2024
  • 3 min read
Urgent Need for Newborn Antibiotics: Insights from Global Health Experts

Leading global public health experts, including those from India, emphasize an urgent call to develop antibiotics specifically tailored for newborn babies. This vulnerable population faces heightened risks associated with antibiotic resistance, necessitating immediate action. Recent statistics reveal that approximately 2.3 million newborns succumb to severe bacterial infections annually, with an alarming rise in resistance to existing antibiotics. The experts’ insights are detailed in a report published in the December 2022 edition of the Bulletin of the World Health Organization.

Escalating Antibiotic Resistance

Over the past decade, antimicrobial resistance (AMR) has escalated significantly, with approximately 50-70 per cent of common pathogens exhibiting substantial resistance to first and second-line antibiotics. This concerning trend underscores the critical need for novel antibiotic solutions tailored to the unique vulnerabilities of newborns.

Collaborative Efforts and Global Consensus

The report, co-authored by international AMR experts from the Global Antibiotic Research & Development Partnership (GARDP) and All India Institute of Medical Sciences (AIIMS), stresses the importance of identifying high-priority antibiotics specifically effective and safe for children. Mike Sharland from St George’s, University of London (SGUL) emphasizes the necessity for a global consensus to expedite antibiotic development, ensuring rapid access and mitigating AMR’s impact on neonatal health.

Collaborative Antibiotic Development

The authors highlight the efficacy of collaborative networks focusing on antibiotic development for newborns. Collaborative efforts, exemplified by partnerships between GARDP, Penta – Child Health Research, SGUL, and other stakeholders, have yielded promising outcomes. For instance, a global observational study involving 3,200 infants with neonatal sepsis across 19 hospitals in 11 countries demonstrated the potential of collaborative research initiatives. This success underscores the value of collaborative antibiotic development networks, streamlining research efforts and expediting access to crucial treatments.

Ongoing Clinical Trials and Challenges

Partnerships are actively engaged in ongoing clinical trials, with an upcoming trial scheduled to commence in South Africa before expanding to other regions. However, challenges persist, including limited antibiotic options adequately studied for newborns, ethical considerations, logistical hurdles, and regulatory complexities hindering clinical research in this demographic. Despite the approval of numerous antibiotics for adult use since 2000, only a handful have comprehensive dosing information tailored to newborns, further underscoring the pressing need for concerted action in this domain.

Conclusion

The urgent demand for newborn-specific antibiotics calls for collaborative efforts, global consensus, and streamlined regulatory frameworks to address critical gaps in antibiotic development and combat rising AMR threats among neonates. With ongoing initiatives and collaborative partnerships, there’s optimism for advancing research, enhancing treatment options, and safeguarding the vulnerable neonatal population from antibiotic-resistant infections.

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Saki Yamamoto

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